concept

COGNITIVE DECLINE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about COGNITIVE DECLINE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

507Connections

0Hypotheses

3Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	COGNITIVE DECLINE
Key Genes/Proteins	TAU, AMYLOID-BETA, APOE
Related Diseases	NEURODEGENERATION, STROKE, NEUROGENESIS, INFLAMMATION

Wiki Pages (20)

Knowledge base pages for this entity

cbs-psp-daily-action-plan

therapeutic · 30834 words

→

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

therapeutic · 15794 words

→

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

→

Clinical Management Guide for CBS/PSP

therapeutic · 15224 words

→

Progressive Supranuclear Palsy (PSP)

disease · 12907 words

→

Pathway Diagram

graph TD
    COGNITIVE_DECLINE["COGNITIVE DECLINE"]
    style COGNITIVE_DECLINE fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    Parkinson_s_Disease["Parkinson's Disease"] -->|"causes"| COGNITIVE_DECLINE
    Lecanemab{"Lecanemab"} -->|"treats"| COGNITIVE_DECLINE
    Donanemab{"Donanemab"} -->|"treats"| COGNITIVE_DECLINE
    Alzheimer_s_Disease["Alzheimer's Disease"] -->|"causes"| COGNITIVE_DECLINE
    Postoperative_Cognitive_Dysfun["Postoperative Cognitive Dysfunction"] -->|"causes"| COGNITIVE_DECLINE
    Type_2_Diabetes_Mellitus["Type 2 Diabetes Mellitus"] -->|"causes"| COGNITIVE_DECLINE
    Cognitive_Resilience(Cognitive Resilience) -.->|"protects against"| COGNITIVE_DECLINE
    LRP1_targeted_Polymersomes["LRP1-targeted Polymersomes"] -.->|"protects against"| COGNITIVE_DECLINE
    APOE4([APOE4]) -->|"risk_factor_for"| COGNITIVE_DECLINE
    Tau_Pathology["Tau Pathology"] -->|"causes"| COGNITIVE_DECLINE

Outgoing (84)

Target	Relation	Type	Str
NEURODEGENERATION	stabilizes	phenotype	0.70
TAU	regulates	protein	0.70
ADUCANUMAB	interacts_with	drug	0.70
STROKE	protects_against	disease	0.70
STROKE	stabilizes	disease	0.70
STROKE	inhibits	disease	0.70
STROKE	activates	disease	0.70
STROKE	treats	disease	0.70
NEUROGENESIS	increases_risk	phenotype	0.70
CREB	targets	gene	0.65
AMYLOID PET	regulates	biomarker	0.65
AMYLOID	exacerbates	protein	0.65
NEURONS	exacerbates	cell_type	0.65
NECROPTOSIS	inhibits	phenotype	0.65
SYNAPTIC PLASTICITY	regulates	phenotype	0.65
NEUROGENESIS	activates	phenotype	0.65
METFORMIN	activates	drug	0.65
STROKE	interacts_with	disease	0.65
NEURODEGENERATION	treats	disease	0.65
SYNAPTIC PLASTICITY	activates	phenotype	0.65
NLRP3	inhibits	gene	0.65
NLRP3	activates	gene	0.65
NLRP3 INFLAMMASOME	regulates	pathway	0.65
SYNAPTIC PLASTICITY	treats	phenotype	0.65
TAU	activates	protein	0.65
ALZHEIMER'S DISEASE	increases_risk	disease	0.65
NEURODEGENERATION	regulates	disease	0.65
CSF	stabilizes	phenotype	0.60
CSF	inhibits	phenotype	0.60
NEURODEGENERATION	biomarker_for	disease	0.60
ALZHEIMER'S DISEASE	expressed_in	disease	0.55
ALZHEIMER'S DISEASE	implicated_in	disease	0.55
RAPAMYCIN	associated_with	drug	0.50
HYPOTHALAMUS	associated_with	brain_region	0.50
DASATINIB	associated_with	drug	0.50
QUERCETIN	associated_with	drug	0.50
CORTEX	associated_with	brain_region	0.50
WHITE MATTER	associated_with	brain_region	0.50
ADUCANUMAB	associated_with	drug	0.50
ENTORHINAL CORTEX	associated_with	brain_region	0.50
CA1	associated_with	brain_region	0.50
CA3	associated_with	brain_region	0.50
DEFERIPRONE	associated_with	drug	0.50
SEMAGLUTIDE	associated_with	drug	0.50
MMSE	associated_with	biomarker	0.50
VISUAL CORTEX	associated_with	brain_region	0.50
FDG-PET	associated_with	biomarker	0.50
LECANEMAB	associated_with	drug	0.45
DONANEMAB	associated_with	drug	0.45
MTOR SIGNALING	associated_with	pathway	0.45

Incoming (423)

Source	Relation	Type	Str
APOE	associated_with	entity	0.90
TAU	implicated_in	entity	0.85
TAU	stabilizes	protein	0.70
AMYLOID-BETA	exacerbates	protein	0.70
APOE	regulates	gene	0.70
INFLAMMATION	treats	phenotype	0.70
APOE	exacerbates	gene	0.70
NEUROINFLAMMATION	exacerbates	phenotype	0.70
APOE	increases_risk	gene	0.70
PDGF	exacerbates	gene	0.70
PDGF	causes	gene	0.70
TDP-43	exacerbates	gene	0.70
CX3CR1	exacerbates	gene	0.70
CX3CR1	treats	gene	0.70
HUNTINGTON'S DISEASE	causes	disease	0.70
HUNTINGTON'S DISEASE	regulates	disease	0.70
APP	activates	gene	0.70
APP	regulates	gene	0.70
PERICYTE	protects_against	cell_type	0.70
PERICYTE	stabilizes	cell_type	0.70
HDAC3	inhibits	gene	0.70
NEUROGENESIS	exacerbates	phenotype	0.70
APP	inhibits	gene	0.70
CYP46A1	exacerbates	gene	0.70
CYP46A1	protects_against	gene	0.70
GABA	inhibits	phenotype	0.70
SYNAPTIC LOSS	treats	phenotype	0.70
ASTROCYTES	protects_against	cell_type	0.70
ASTROCYTES	exacerbates	cell_type	0.70
ASTROCYTES	causes	cell_type	0.70
TREM2	exacerbates	gene	0.70
TNF	exacerbates	gene	0.70
APOE	protects_against	gene	0.70
TAU	biomarker_for	protein	0.65
SEPSIS	causes	disease	0.65
SENESCENCE	causes	phenotype	0.65
AGING	increases_risk	phenotype	0.65
MICROGLIA	exacerbates	cell_type	0.65
APP	exacerbates	gene	0.65
BDNF	treats	gene	0.65
APP	protects_against	gene	0.65
NEURON	causes	cell_type	0.65
ALZHEIMER'S DISEASE	exacerbates	disease	0.65
SIRT2	exacerbates	gene	0.65
SEMAGLUTIDE	treats	drug	0.65
NEUROFIBRILLARY TANGLES	interacts_with	phenotype	0.65
GLIOSIS	regulates	phenotype	0.65
CORTEX	causes	brain_region	0.65
TAU	produces	protein	0.65
NLRP3 INFLAMMASOME	causes	pathway	0.65

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (3)

Scientific analyses that reference this entity

Quantitative proteomics of the aging synapse in early Alzheimer disease

neurodegeneration | 2026-04-04 | 0 hypotheses

Human connectome alterations and network-level dysfunction in Alzheimer disease

neurodegeneration | 2026-04-04 | 0 hypotheses

Synaptic pruning by microglia in early AD

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.503

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

COGNITIVE DECLINE

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Clinical Management Guide for CBS/PSP

Progressive Supranuclear Palsy (PSP)

Novel Therapy Index

Parkinson's Disease

Sleep and Circadian Dysfunction in Alzheimer's Disease

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

CBS/PSP Supplements Guide

Device Therapies Comparison for CBS/PSP

CBS/PSP Rehabilitation Master Guide

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

Alpha-Synuclein Pathology

Myoclonus and Cortical Hyperexcitability in Corticobasal Syndrome

PD Combination Therapy Matrix

Alzheimer's Disease Mechanism Index

Corticobasal Degeneration (CBD)

nhp-validation-animal-model

Neuroresilience Mechanisms and Evidence